Giovanni Marzaro

tUning New COmpounds against the VIrus: Development of specific inhibitors – UNCOVID

Required Budget: 30.000 euro

Our project aims at the development of new molecules able to prevent and/or treat SARS-CoV-2 infection, thus improving the potency of those drugs (already used for other therapeutic purposes) that are showing only partial inhibition of the virus and that we are currently identifying thanks to a study recently funded by the Cariparo Foundation.

The development of these new molecules will therefore: 1) provide new potential drug candidates for the treatment of SARS-CoV-2; 2) increase knowledge about the structural requirements necessary for interaction with the viral proteins responsible for the infection and propagation of the virus. In this perspective, the development of molecules able to interact with essential and highly conserved proteins in different types of coronavirus (such as SARS, MERS, SARS-CoV-2), will ensure a faster development of additional pharmacological tools in case of SARS-CoV-2 mutations and/or the future appearance of new epidemic strains of coronavirus.